Christopher Little, MD

Dr. Christopher Little



Appleton, WI

Medical School:

University of Wisconsin School of Medicine & Public Health

Additional Education:

University of Wisconsin Transplant Research Training Program

Resident Bio:

I am in the research track of the general surgery program here at the University of Washington. I was raised in a Navy family, originally from Jacksonville, FL. We moved around the southeast coast before settling in Appleton, WI. I went to both undergrad and medical school at the University of Wisconsin in Madison, before moving to Seattle for residency. I am planning to pursue a career in abdominal transplant surgery, with research interests in transplant immunology and organ allocation strategies

Personal Interests:


Clinical Interests:

Transplant surgery

Professional Activities:

Translational research, clinical research, education

Why UW?

Strong and diverse patient care experiences across our various hospitals

What advice do you have for incoming interns?

Work hard and take care of one another

What do you like best about living in Seattle?

Seattle Thunderbird hockey


Little CJ, Dick AAS, Perkins JD, Hsu EK, Reyes JD. Livers from pediatric donation after circulatory death donors represent a viable and underutilized source of allograft. Liver Transpl. 2020;26(9):1138-1153.

Zhang M, Urabe G, Little C, Wang B, Kent A, Huang Y, Kent KC, Guo LW. HDAC6 regulates the MRTF-A/SRF axis and vascular smooth muscle cell plasticity. JACC Basic Transl Sci. 2018;3(6):782-795.

Grodstein EI, Little C, Molmenti EP, Mezrich JD. Renal transplantation as a platform for teaching residents open vascular surgical techniques: effects on early graft function. J Surg Educ. 2018;75(4):964-967.

Zhu Y, Takayama T, Wang B, Kent A, Zhang M, Binder B, Urabe G, Shi Y, DiRenzo D, Goel S, Zhou Y, Little C, Roenneburg D, Shi XD, Li L, Murphy W, Kent KC, Ke J, Guo LW. Restenosis inhibition and re-differentiation of TGFβ/Smad3-activated smooth muscle cells by resveratrol. Sci Rep. 2017;7:41916.

Guo LW, Wang B, Goel SA, Little C, Takayama T, Shi XD, Roenneburg D, DiRenzo D, Kent KC. Halofuginone stimulates adaptive remodeling and preserves re-endothelialization in balloon-injured rat carotid arteries. Circ Cardiovasc Interv. 2014;7(4):594-601.

Zhang J*, Little CJ*, Tremmel DM, Yin JCP, Wesley CS. Notch-inducible hyperphosphorylated CREB and its ultradian oscillation in long-term memory formation. J Neurosci. 2013;33(31):12825-12834. (*co-first authors)

Tremmel DM, Resad S, Little CJ, Wesley CS. Notch and PKC are involved in formation of the lateral region of the dorso-ventral axis in Drosophila embryos. PLoS One. 2013;8(7):e67789.