Little, Christopher

I am in the research track of the general surgery program here at the University of Washington. I was raised in a Navy family, originally from Jacksonville, FL. We moved around the southeast coast before settling in Appleton, WI. I went to both undergrad and medical school at the University of Wisconsin in Madison, before moving to Seattle for residency. I am planning to pursue a career in abdominal transplant surgery, with research interests in transplant immunology and organ allocation strategies.

Translational research, clinical research, education

1. Little CJ, Leverson GE, Hammel LL, Connor JP, Al-Adra DP. Blood Products and Liver Transplantation: A Strategy to Balance Optimal Preparation with Effective Blood Stewardship. Tranfusion. In print
2. Kim SC, Bolognese AC, Little CJ, Hitchcock ME, Leverson GE, Al-Adra DP. Liver transplantation for hepatocellular carcinoma with bile duct tumor-associated thrombi: a systematic review and pooled analysis. Front Transplant. 2022;1:879056.
3. Little CJ, Haynes WJ, Huang L, Daffada CM, Wolfe KB, Perrin E, Simpson JA, Kropp Schmidt JA, Hinkle HM, Keding LT, Behrens RT, Evans DT, Kaufman DB, Thomson JA, Golos TG, Brown ME. Robust engraftment of fetal nonhuman primate CD34-positive cells in immune-deficient mice. J Leukoc Biol. Published online March 30, 2022.
4. Lema DA, Jankowska-Gan E, Nair A, et al. Cross-decoration of dendritic cells by non-inherited maternal antigen-containing extracellular vesicles: Potential mechanism for PD-L1-based tolerance in cord blood and organ transplantation. Am J Transplant. 2022;22(5):1329-1338.
5. Forrest L, Fechner J, Post J, Van Asselt N, Kvasnica K, Haynes LD, Coonen J, Brunner K, Haynes WJ, Little C, Burlingham W, Hematti P, Strober S, Kaufman D. Tomotherapy applied total lymphoid irradiation and allogeneic hematopoietic cell transplantation generates mixed chimerism in the rhesus macaque model. Radiat Res. 2021;196(6):623-632.
6. Little CJ, Dick AAS, Perkins JD, Reyes JD. Donor-recipient BSA matching is prognostically significant in solitary and en bloc kidney transplantation from pediatric circulatory death donors. Transplant Direct. 2021;7(8):e733.
7. Little CJ, Dick AAS, Perkins JD, Hsu EK, Reyes JD. Livers from pediatric donation after circulatory death donors represent a viable and underutilized source of allograft. Liver Transpl. 2020;26(9):1138-1153.
8. Zhang M, Urabe G, Little C, Wang B, Kent A, Huang Y, Kent KC, Guo LW. HDAC6 regulates the MRTF-A/SRF axis and vascular smooth muscle cell plasticity. JACC Basic Transl Sci. 2018;3(6):782-795.
9. Grodstein EI, Little C, Molmenti EP, Mezrich JD. Renal transplantation as a platform for teaching residents open vascular surgical techniques: effects on early graft function. J Surg Educ. 2018;75(4):964-967.
10. Zhu Y, Takayama T, Wang B, Kent A, Zhang M, Binder B, Urabe G, Shi Y, DiRenzo D, Goel S, Zhou Y, Little C, Roenneburg D, Shi XD, Li L, Murphy W, Kent KC, Ke J, Guo LW. Restenosis inhibition and re-differentiation of TGFβ/Smad3-activated smooth muscle cells by resveratrol. Sci Rep. 2017;7:41916.
11. Guo LW, Wang B, Goel SA, Little C, Takayama T, Shi XD, Roenneburg D, DiRenzo D, Kent KC. Halofuginone stimulates adaptive remodeling and preserves re-endothelialization in balloon-injured rat carotid arteries. Circ Cardiovasc Interv. 2014;7(4):594-601.
12. Zhang J, Little CJ, Tremmel DM, Yin JCP, Wesley CS. Notch-inducible hyperphosphorylated CREB and its ultradian oscillation in long-term memory formation. J Neurosci. 2013;33(31):12825-12834.
13. Tremmel DM, Resad S, Little CJ, Wesley CS. Notch and PKC are involved in formation of the lateral region of the dorso-ventral axis in Drosophila embryos. PLoS One. 2013;8(7):e67789.