Investigator Profile: Lena Sibulesky, MD
Lena Sibulesky, MD
Associate Professor, Division of Transplant Surgery
Dr. Sibulesky research interest is investigating the mechanism of biliary stricture formation (ischemic cholangiopathy/ischemic-type biliary stricture) in donor after cardiac death (DCD) liver allografts. Understanding the molecular mechanism of the stricture formation will allow effective therapies to ameliorate ITBS in liver transplantation. Overcoming the major complication of ITBS will potentially lead to significant expansion in donor livers in an era of increasing organ shortage.
Department of Surgery Research Reinvestment Fund (Sibulesky) 01/2014 – 01/2015
Oxidative Injury to Biliary Epithelial Leading to Biliary Strictures in DCD Liver Allografts
- Hori T, Ueda M, Oike F, Ogura Y, Ogawa K, Nguyen JH, Yonekawa Y, Takada Y, Egawa H, Yoshizawa A, Sibulesky L, Balci D, Chen F, Baine AM, Uemoto S. Graft loss and poor outcomes after living-donor liver transplantation owing to arterioportal shunts caused by liver needle biopsies. Transplant Proc. 2010 Sep; 42(7):2642-4. PMID:20832560. DOI:10.1016/j.transproceed.2010.04.032.
- Adkisson CD, Sibulesky L, Collis GN, McLaughlin DW, Oldenburg WA, Nguyen JH. Aneurysmectomy and revascularization of a large hepatic artery aneurysm. Ann Vasc Surg. 2011 May; 25(4):556.e11-5. PMID:21549927. DOI:10.1016/j.avsg.2010.09.025.
- Sibulesky L, Heckman MG, Perry DK, Taner CB, Willingham DL, Nguyen JH. A single-center experience with biliary reconstruction in retransplantation: duct-to-duct or Roux-en-Y choledochojejunostomy. Liver Transpl. 2011 Jun; 17(6):710-6. PMID:21618692. DOI:10.1002/lt.22263.
- Sibulesky L, Nguyen JH. Update on biliary strictures in liver transplants. Transplant Proc. 2011 Jun; 43(5):1760-4. PMID:21693274. DOI:10.1016/j.transproceed.2010.12.057.
- Perry DK, Willingham DL, Sibulesky L, Bulatao IG, Nguyen JH, Taner CB. Should donation after cardiac death liver grafts be used for retransplantation? Ann Hepatol. 2011 Oct-Dec; 10(4):482-5. PMID: 21911889
- Sibulesky L, Shine TS, Nguyen JH. A surgical technique for portal vein decompression in retransplantation. J Gastrointest Surg. 2011 Nov; 15(11):2098-100. Epub 2011 Sep 21. PMID: 21935734. DOI:10.1007/s11605-011-1679-3
- Taner CB, Bulatao IG, Willingham DL, Perry DK, Sibulesky L, Pungpapong S, Aranda-Michel J, Keaveny AP, Kramer DJ, Nguyen JH. Events in procurement as risk factors for ischemic cholangiopathy in liver transplantation using donation after cardiac death donors. Liver Transpl. 2012 Jan; 18(1):100-11. PMID:21837741. DOI:10.1002/lt.22404
- Sibulesky L, Nguyen J, Patel T. Preneoplastic conditions underlying bile duct cancer. Langenbecks Arch Surg. 2012 Aug; 397(6):861-7. Epub 2012 Mar 06. PMID:22391777. DOI:10.1007/s00423-012-0943-7
- Taner CB, Bulatao IG, Perry DK, Sibulesky L, Willingham DL, Kramer DJ, Nguyen JH. Asystole to cross-clamp period predicts development of biliary complications in liver transplantation using donation after cardiac death donors. Transpl Int. 2012 Aug; 25(8):838-46. Epub 2012 Jun 15. PMID:22703372. DOI:10.1111/j.1432-2277.2012.01508.x.
- Taner CB, Bulatao IG, Arasi LC, Perry DK, Willingham DL, Sibulesky L, Rosser BG, Canabal JM, Nguyen JH, Kramer DJ. Liver transplantation in the critically ill: donation after cardiac death compared to donation after brain death grafts. Ann Hepatol. 2012 Sep; 11(5):679-85. PMID: 22947529
- Sibulesky L, Heckman MG, Taner CB, Canabal JM, Diehl NN, Perry DK, Willingham DL, Pungpapong S, Rosser BG, Kramer DJ, Nguyen JH. Outcomes following liver transplantation in intensive care unit patients. World J Hepatol. 2013 Jan 27;5(1):26-32. doi: 10.4254/wjh.v5.i1.26. PMID: 23383363
- Burcin Taner C, Bulatao IG, Perry DK, Sibulesky L, Wllingham DL, Kramer DJ, Nguyen JH. Agonal period in donation after cardiac death donors. Transpl Int. 2013 Mar;26(3):e17-8. doi: 10.1111/tri.12056. PMID: 23405915
- Sibulesky L, McKinney JM, Nguyen JH, Satyanarayana R. Hepatic encephalopathy without cirrhosis. Am J Transplant. 2013 Nov;13(11):3045-7. DOI: 10.1111/ajt.12347. PMID:24164911
- Sibulesky L, Gohh R, Charpentier K, Morrissey P. Kidney transplantation from donors with severe disseminated intravascular coagulation.ISRN Transplantation. Volume 2013 (2013), Article ID 646310, http://dx.doi.org/10.5402/2013/646310
- Sibulesky L. Normal liver anatomy. Clinical Liver Disease 2013 March Volume 2, Issue Supplement S1, pages S1–S3. DOI: 10.1002/cld.124