The goal of the UW TIME Lab is to develop a precise understanding of the nature of the adaptive immune response to solid tumors, in order to develop effective immunotherapies. While much of our work focuses on pancreatic and colorectal carcinoma, we are particularly interested in shedding light on aspects of tumor biology that reach across many tumor types. Our central goal is to address is how the immunosuppressive microenvironment created by solid tumors can be altered to enable reactivation of endogenous T cell responses. In concert with this work, we are also finding that adoptively transferred T cells (e.g. CAR-T cells) are subject to similar mechanisms of immunosuppression in the TIME.

Nick Crispe
Professor of Pathology
Adjunct Professor of Immunology
University of Washington

Albert Folch
Professor of Engineering
University of Washington

Taran Gujral
Assistant Professor
Fred Hutchinson Cancer Center

Steven Katz
Chairman, Immuno-oncology Institute (Ix2)
Chief, Immunotherapy Service, Department of Medicine
Associate Professor of Surgery
Roger Williams Medical Center

Teresa Kim
Assistant Professor of Surgery
Co-PI, UW TIME Lab
University of Washington

Jonathan Liu
Associate Professor, Mechanical Engineering
Adjunct Associate Professor, Bioengineering
Adjunct Associate Professor, Laboratory Medicine and Pathology
University of Washington

Joshua Veatch
Acting Instructor, Department of Medicine
Fred Hutchinson Cancer Center
University of Washington

Raymond Yeung
Professor of Surgery
University of Washington

Dr. Venu Pillarisetty’s UW Medicine Biography >>